TopRx has partnered with Express222™ to process Schedule II controlled substance online orders. Express222™ is the simplest, most cost-effective answer for eliminating the paper Form 222 and ensuring DEA compliance. This web-based Controlled Substance Ordering System (CSOS) delivers all the benefits of electronic controlled substance ordering and fulfillment with some surprising differences:

  • No complex system configurations or EDI requirements
  • No cumbersome setup wizards or profiles
  • No forced changes to your current operational processes
  • No requirement to integrate to existing in-house solutions

If you’ve already registered, click here to Login to CSOS
Or contact CustomerService@toprx.com to initiate your CSOS enrollment.

Customer Guide to CSOS Enrollment

The Drug Enforcement Administration (DEA) Controlled Substance Ordering System (CSOS) allows for secure electronic transmission of Schedule II controlled substance orders without the supporting paper Form 222. The electronically transmitted order contains a digital version of a traditional written signature. The digital signature is accomplished using a computer file known as a digital certificate.

Placing an Order

Once you are notified by your TopRx Account Manager that your CSOS enrollment is complete, you will receive an Enrollment Guide which provides step by step instructions to finalize enrollment.

After logging on to Express222 you are now ready to create an order by selecting the Create, Send, and Manage e222 Forms. If prompted, select TopRx as your trading partner.

Select Create a New Order and choose the Schedule II controlled substances you wish to order. Once you have added the desired product select Save Form and Continue.

This will bring you to the Order Disposition screen which allows you to update any personal contact information. The order can be sent now by selecting Send Order Now or send later by selecting Save and Exit Without Sending.

When prompted, enter your Certificate Store Password used for signing e222 forms.

You can utilize the Express222 Sent Orders screen to see orders sent to TopRx. You will receive an order confirmation email once an order has been sent for processing.

Should you experience any issues or have questions, please contact CustomerService@toprx.com and copy your Account Manager.